Glucocorticoid Receptors in Mouse Mammary Tumors
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منابع مشابه
Glucocorticoid receptors in mouse mammary tumors. Specific binding of glucocorticoids in the cytoplasm.
Specific binding of glucocorticoids was studied in the cytoplasmic extracts of mouse mammary tumors induced by mammary tumor virus. The binding protein satisfied all the general criteria of hormone receptors namely a specific high affinity for glucocorticoids (4 X 10mg M for dexamethasone) and limited number of binding sites which were saturated with low hormone concentrations (1 X 1OV M). It i...
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The influence of cortisol and prolactin on casein gene expression in the mammary gland of lactating BALB/c mice was measured by using a specific cDNA probe to 15S casein mRNA (cDNAcsn). Casein mRNA (mRNAcsn) level in the mammary gland was decreased by 85% 5 days after adrenal ablation, but then was increased 4.4-fold 12 hr after a single injection of hydrocortisone-21-acetate. An 80% decrease i...
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Hormone-dependent (HD) Grunder strain mouse mammary carcinomas contain a 65-kDa estrogen receptor (ER) with minor amounts of 50- and 35-kDa components which apparently still contain the intact hormone-binding (COOH-terminal) domain. When the HD tumors lose their hormonal dependence during serial transplantation, the hormone-independent (HI) transplants show an increase in 50- and 35-kDa compone...
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Saturable, high-affinity binding sites for 3,5,3'-triiodo-L-thyronine (T3) were identified in isolated nuclei and solubilized chromatin extracts of mammary glands, spontaneous mammary tumors, and liver from C3H/HeN mice. Receptor concentration in whole mammary gland nuclei (254 fmol/mg DNA) was only about one-half that of mouse liver nuclei (536 fmol/mg DNA), but in molecular weight (55,000) an...
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Saturable, high-affinity binding sites for 3,5,3'-triiodo-u-thyronine (T3) were identified in isolated nuclei and solubilized chromatin extracts of mammary glands, spontaneous mam mary tumors, and liver from C3H/HeN mice. Receptor concen tration in whole mammary gland nuclei (254 fmol/mg DMA) was only about one-half that of mouse liver nuclei (536 fmol/ mg DNA), but in molecular weight (55,000)...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1974
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)42812-3